In 1872 Henry and Fanny started the East London Missionary Training Institute (also called Harley College) at Harley House in London. The renowned Dr. Thomas Barnardo was co-director with Henry and was greatly influenced by him. The Regions Beyond Missionary Union would also be founded here, an agency which is an ancestor of Latin Link. Henry also founded the Livingstone Inland Mission in 1877.
The college was so successful that it needed a new site and it moved to Derbyshire. The Guinnesses raised and spent thousands of pounds refurbishing the site, which is today the home of Cliff College.
In 1879, Henry travelled to Algeria and saw the need there. The next year, George and Jane Pearse would approach him for guidance on starting work there and he would donate to help begin The Mission to the Kabyles (later the North Africa Mission). Henry and Fanny would both serve on the council of the mission in those early years.
Fanny died in 1893 and Henry would go on to remarry in 1903. He and Grace, his second wife, would travel across the world on a missionary tour for the next five years. Returning in 1908, Henry died in Bath in 1910, leaving behind a family who would themselves be remarkable servants of the Lord.
Henry and Fanny’s daughter, Mary, married the son of Hudson Taylor. Lucy, another daughter, married Karl Kumm, the founder of the SUM (today Pioneers UK), whom she met when visiting Egypt with her father.